Low dose tadalafil effect on anthropometric and metabolic parameters in Iraqi diabetic obese men

  • Faris AK Khazaal Obesity research and therapy unit, Al-Kindy college of medicine, Baghdad University


Background: Phosphodiesterase-5 (PDE-5) inhibitors restore nitric oxide (NO) signaling and may reduce circulating inflammatory markers, and improve metabolic parameters through a number of mechanisms. Daily administration of the PDE-5 inhibitor, tadalafil (TAD) may attenuate inflammation; improve fasting plasma glucose and triglyceride levels and body weight. This study aims to evaluate the efficacy of low dose PDE-5 inhibitor, tadalafil (TAD) in controlling dysglycemia and body weight in obese diabetic men.
Methods: Forty obese men with type 2 diabetes aged 30-50 years incorporated in this study, all with A1c of 7-8.5%, attending obesity unit in AL-Kindy college of medicine. Weight, height, BMI, FPG, A1c, cholesterol, TG, HDL and LDL measured for all and advised for low calories diet and
increasing exercise and randomized into 2 groups , first (control) without and the second (therapy) with addition of tadalafil 2.5mg/day for 8 weeks, then remeasure all the parameters after. Results blotted in tables and statistical analysis done using SPSS program and t-test.
Results: There was significant reduction in weight, BMI, FPG, cholesterol, TG and LDL, while no significant change in A1c , and although there was elevation in HDL but was insignificant in control group. In therapy group both weight, BMI, FPG, A1c, cholesterol, TG, and LDL show significant reduction, with mild insignificant elevation in HD. When compare the results of both groups significant results appear in percentage of change of FPG and A1c in therapy group.
Conclusion: Low calories diet and exercise are effective in reducing obesity parameters in type 2 diabetes, in addition, improve dysglycemia and dyslipidemia , adding tadalafil 2.5mg/day can add beneficial effect specifically for FPG and A1c significantly.